1μm轴向分辨率敏感OCT系统由Galahad项目提供,具有一系列新的OCT产品

2020年2月17日的Ilminster

G&H announces that the EU GALAHAD project has now been completed.GALAHAD(Glaucoma – Advanced, LAbel-free High resolution Automated OCT Diagnostics; was funded by the European Union through its Horizon 2020 programme. Co-ordinated by G&H Torquay, the project brought together ten partners from across Europe with the common objective of developing hardware, software and know-how to improve the early screening of glaucoma.

UHR-PS-OCT设备成像人类志愿者。
UHR-PS-OCT设备成像人类志愿者。

GALAHAD finished on schedule at the end of November 2019. Over the last 36 months the project has had a major impact on the development of ultra-high resolution polarisation sensitive optical coherence tomography (UHR-PS-OCT), from advances in components to automated algorithms to process the results. GALAHAD has been very successful in developing components, sub-systems, operational systems (1 µm axial resolution), processes and software related to OCT and has achieved some important results in applying them to glaucoma screening. The key advances include:

  • Hardware for UHR-PS-OCT
    • Components (already available as products from G&H)
      • G&H has set the new state-of-the-art in both SM and PM broadband fused fiber components and has a wide range of new products already on the market
      • PM and SM collimators
      • SM and PM delay lines
      • 电动极化控制器
      • Variable dispersion compensator
    • Sources (products planned to be released in 2020 by NKT)
      • nkt photonics.has developed the first polarised supercontinuum source with a long lifetime and robust polarisation extinction ratio (>25 dB PER for >2200 h successful operation)
      • Technical University of Denmark(DTU)对超级连续来源的噪声过程的理解作出了根本性进展
    • Spectrometers (customized products available fromIBSEN PHIGONICS.)
      • Ibsen has improved its technology from the large area etch process for its gratings to improved thermal stability for its spectrometers
    • 软件for UHR-PS-OCT
      • DTU developed numerical all-depth OCT dispersion compensation software
      • Universitat Politècnica de València(UPV)开亚搏开户网址发的算法,将新的最先进的算法设置在几个方面:
        • Retinal layer segmentation algorithms for体内ex vivorodent OCT images
        • Computer-aided diagnosis algorithms for glaucoma from human OCT images
        • 表皮和毛囊分割算法用于人体皮肤OCT图像
        • Gloucestershire Hospitals NHS Foundation Trusthas made available a large anonymised human glaucoma OCT database
      • Standards for UHR-PS-OCT
        • University of Münster(WWU) delivered permanent tissue-like test standards for UHR-PS-OCT testing
        • WWU reported the first measurement of retinal refractive index as a function of wavelength
      • 系统for UHR-PS-OCT
        • Optos组装了两个最终系统,其特征在于1.25μm(Galahad-1)和1.39μm(Galahad-2)的轴向分辨率。
      • Preliminary observations with the GALAHAD UHR-PS-OCT systems
        • >执行来自各种青光眼模型的10月OCT测量
          • GALAHAD standard mouse retina models at WWU
          • Standard test targets and体内啮齿动物视网膜模型Rigshospitalet,哥本哈根
          • Thanks to excellent progress and efforts at Optos, it was possible to demonstrate the systems on a human volunteer
        • 这项工作已经为Rigshospitalet进行了分析程序的分析程序,用于对视野特征的精细分析预测
      • Demonstration of GALAHAD UHR-PS-OCT system
        • 这次现场演示,在人类志愿者,于2020年1月8日组成的研讨会的一部分到研究人员和临床医生的受众
        • This went significantly beyond the planned project scope and was a highly satisfactory conclusion to the project.
1μm用Galahad PS OCT器件拍摄的人类志愿者的轴向分辨率图像。刻度条显示深度为100μm。图像是单圆扫描(即没有平均值)。
1μm用Galahad PS OCT器件拍摄的人类志愿者的轴向分辨率图像。刻度条显示深度为100μm。图像是单圆扫描(即没有平均值)。

This document outlines the material available in the public domain. More detail may be found at the projectwebsite. For further information, please contactBruce Napier.

这个项目已经收到资金从地平线2020, the European Union’s Framework Programme for Research and Innovation, under grant agreement No. 732613.